Shakespeare and... Science Fiction?

I was looking at my friend's book, and just really fell in love with the cover design. It was a sketch of a circular building. The view was from an overhead angle, so you could really see the curved shape supported by cross-hatched rafters-- it looked like a giant wheel, or some whimsical wind mill, or best yet-- a flying saucer. A week later I realized the illustration was of Shakespeare's Globe Theater.

If we let ourselves imagine Shakespeare staging plays inside a UFO, what other other-worldly correlatives can we find in The Bard's text? Themes of isolation, alienation, loss of identity, the uncanny... all themes of Shakespeare, all themes of Sci-fi. It is worth noting that (who we think of as "timeless") Shakespeare was socio-politically lodged in a important notch in history: the Protestant Reformation. It was this event that set the stage for our present industrial, globalized, postmodern circumstances. This event was the birth of the new world and the new human. Shakespeare wrote science fiction.